Devon Dotson had 20 points and six assists, David McCormack added 16 points and seven rebounds and No. 3 Kansas routed Iowa State 79-53.
The Jayhawks closed the first half with a 21-3 run to take a 20-point lead.
They improved to 12-2 overall and 2-0 in the Big 12, handing Iowa State its most-lopsided loss in the series since an 89-66 setback Feb. 12, 2011, in Lawrence.
Kansas held star Iowa State guard Tyrese Haliburton to five points.